Introduction
Men seeking penile enhancement have historically faced limited options, many of which come with significant drawbacks. Traditional approaches have included dermal fillers, fat transfer procedures, traction devices, suspensory ligament surgery, and silicone implants. While each of these methods addresses certain concerns, none has successfully improved length, girth, and sexual function simultaneously while maintaining a strong safety profile.
A pilot study published in The Journal of Sexual Medicine in February 2024 presents a novel approach called the P-Long Protocol. This IRB-approved research combines platelet-rich plasma (PRP) therapy with complementary treatments to achieve measurable improvements in penile dimensions and erectile function without synthetic injectables or invasive surgery.
Study Citation: Brandeis J, Lu S, Runels C. "A Pilot Study of a Novel PRP Protocol to Increase Penile Length, Girth, and Function." The Journal of Sexual Medicine, Volume 21, Supplement 1, February 2024. DOI: 10.1093/jsxmed/qdae001.219
Study Objective
The P-Long Study was designed to identify a safe and reproducible method for increasing penile length, girth, and function in healthy men. Unlike previous approaches that typically address only one aspect of enhancement, this protocol aimed to achieve comprehensive improvements using the body's own regenerative capabilities.
Study Design and Methodology
Participant Criteria
The study enrolled healthy men between 20 and 55 years of age who demonstrated normal erectile function (SHIM score greater than 22). Exclusion criteria included Peyronie's disease, previous penile interventions, and congenital penile abnormalities. All participants provided informed consent under IRB approval.
Measurement Protocol
Penile measurements were conducted by participants during self-stimulation at full erection without the use of PDE-5 inhibitors or Trimix. Standardized measuring instruments—a transparent rigid ruler for length and a flexible tape measure for circumference—were used, with results documented through digital photography. Measurements were recorded at baseline and monthly throughout the six-month treatment period.
The P-Long Protocol Components
Platelet-Rich Plasma (PRP) Injections
Monthly ultrasound-guided PRP injections into the corpora cavernosa using a specialized double-spin system that concentrates platelets to approximately 6.6 times the baseline level.
Traction Therapy
Daily use of the RestoreX traction device for 20 minutes, twice daily, to stimulate longitudinal tissue growth.
Vacuum Erection Device
Regular use of a penis pump at controlled pressure levels to promote circumferential penile growth through controlled suction therapy.
Nitric Oxide Supplementation
Daily supplementation with L-Citrulline (3g) and beet extract (1g) to enhance blood flow and support nighttime erections.
PRP Preparation Details
The PRP was prepared using a specialized double-spin centrifuge system from 60cc of drawn blood. Technical analysis showed an average platelet recovery of 84% with concentration levels reaching 6.6 times the whole blood baseline. Based on these parameters, each 10cc PRP injection delivered approximately 1.65 billion platelets (assuming a starting platelet count of 250,000 per microliter).
Study Results
+0.81"
Average Length Increase
Paired t-test: t=13.641, p=0.000
+0.47"
Average Girth Increase
Paired t-test: t=13.498, p=0.000
Participant Demographics
29 men completed the full treatment protocol. The mean age was 32 years, with baseline measurements showing an average erect length of 5.70 inches and circumference of 5.25 inches.
After six months of treatment, participants demonstrated statistically significant improvements in both length and girth. Erect penile length increased by an average of 0.805 inches, while circumference increased by an average of 0.469 inches. Both results achieved high statistical significance (p<0.001).
Additionally, all participants reported subjective improvements in erectile function when assessed using a Likert scale questionnaire.
Key Study Findings
- Average increase of 0.81 inches in erect penile length
- Average increase of 0.47 inches in girth (circumference)
- All participants reported improved erectile function
- No synthetic injectables or foreign bodies required
- Six-month treatment protocol with monthly sessions
Conclusions and Clinical Implications
The P-Long Protocol represents a potentially safe approach to achieving meaningful improvements in penile dimensions and function. The study demonstrates that combining PRP therapy with traction, vacuum therapy, and nitric oxide supplementation can produce measurable results without the risks associated with synthetic injectables, foreign body implants, or extensive surgical procedures.
The ultrasound-guided PRP injection technique used in this protocol can be readily taught to urologists and sexual medicine practitioners, making it accessible for clinical implementation. Importantly, this approach does not preclude future augmentation procedures if desired, positioning it as a viable first-line option for men interested in penile enhancement.
The researchers noted that the growth curve observed during the study suggests potential for continued improvement with additional treatment cycles beyond the initial six-month protocol.
Important Note: This study provides clinical guidance for expected outcomes. Individual results may vary based on patient factors, adherence to the protocol, and biological response to treatment.
Disclosure
The original study authors disclosed that one or more authors act as a consultant, employee, or shareholder of AFFIRM Science, which produces the nitric oxide supplement used in the protocol.